Intoxications by lead and its inorganic compounds

Lead belongs to the group of blood poisons that impair synthesis porphyrins and heme. Under industrial conditions, only chronic lead poisoning can develop. have effect material cumulation. The half-life is 20 years. Once in body, it deposited many organs form insoluble tribasic phosphates. A significant part trabeculae bones. influence provoking factors, an intensive release from depot be observed. In such cases, amount circulating increases sharply, remission replaced by exacerbation. There a wavy course intoxication. its inorganic compounds belong polytropic on affecting systems. system (anemia with specific characteristics) nervous (polyneuropathy encephalopathy) are primarily affected. number other systems also most severe syndrome gastrointestinal tract damage colic. Due impaired heme certain biological substrates body — blood, erythrocytes urine, substances unused accumulated. They markers intoxication caused lead, presence relevant clinical picture. diagnosis based data professional history, sanitary hygienic characteristics working objective disease laboratory examination. main thing stop contact remove body. Antidotes for chelators: tetacinum-calcium, pentacinum, D-penicillamine. combination technical sanitary-hygienic measures prevent preliminary periodic medical examinations persons great importance.